Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression

The toxicology and safety of apple polyphenol extract.

Apple polyphenol extract has strong antioxidant activity and various physiological functions, and is used in Japan as a food additive and nutritional supplements. Here, we tested the consumption safety of Applephenon, which is a polyphenol extract produced from unripe apples. The Ames test without S9 mixture revealed that Applephenon, had slight mutagenicity at a high concentration of 2500 micr...

Polyphenol Rich Extract of Garcinia pedunculata Fruit Attenuates the Hyperlipidemia Induced by High Fat Diet

Fatty foods, the most common diet today are the crux of many metabolic disorders which need urgent attention. Garcinia pedunculata Roxb. (GP, Clusiaceae) is a plant found available in Northeast (NE) region of India, is considered to have versatile therapeutic properties. The people of this region has been using dried pulp of GP fruit for the treatment of different stomach related diseases tradi...

eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries.

BACKGROUND/AIMS Drinking red wine is associated with a decreased mortality from coronary heart diseases. This study examined whether polyphenols contained in a grape skin extract (GSE) triggered the endothelial formation of nitric oxide (NO) and investigated the underlying mechanism. METHODS Vascular reactivity was assessed in organ chambers using porcine coronary artery rings in the presence...

Monocytic Cells by Down-Regulating the in Lipopolysaccharide-Stimulated Human Dexamethasone Inhibits IL-12p40 Production

Dexamethasone Inhibits IL-12p40 Production